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Clinical Research

Clinical research builds on the advances of basic and translational research to improve health and reduce the impact of disease and injury. This form of research is typically conducted with human subjects over the period of years. The Duke Department of Neurology is conducting clinical research in several areas, from multiple sclerosis, traumatic brain injury, to nerve pain caused by chemotherapy. We also conduct clinical trials in all major areas of neurology.

The Department of Neurology is a national leader in clinical trials for multiple sclerosis, Alzheimer's disease, and other neurological conditions. Use the links below to find a clinical trial that is actively seeking patients, or read more about clinical trials at Duke.

ALS

(11 currently active or recruiting studies) - Current clinical trials at Duke involving ALS include Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) and Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS. Read more about them here.

Alzheimer's and Dementia

(22 currently active or recruiting studies) - Current clinical trials at Duke involving Alzheimer's or dementia include Caring for Persons With Dementia and Their Caregivers in the Community and Bilateral Brain Dynamics in Cognition and Aging. Read more about them here.

Dystonia

(1 currently active or recruiting study) - Duke is participating in the Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS) study. Read about it and related studies here.

Epilepsy

(7 currently active or recruiting studies) - Current clinical trials for patients with epilepsy at Duke include Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System, and Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study. Read more about them here.

Migraine and Headaches

(3 currently active or recruiting studies) - Current clinical trails for patients with headaches or migraine at Duke include Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments and RCT of SPG Blocks for Post-dural Headache. Read more about them here.

Huntington's Disease

(4 currently active or recruiting studies) - Current clinical trials for patients with Huntington's Disease for patientis with Huntington's disease include Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort and Cooperative Huntington's Observational Research Trial. Read more about them here.

Multiple Sclerosis and Neuroimmunology

(7 currently active or recruiting studies) - Current clinical trails for patients with multiple sclerosis at Duke include MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis and Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease. Read more about them here.

Myasthenia Gravis

(3 currently active or recruiting studies) - Current clinical trails for patients with myasthenia gravis at Duke include Disease-Modifying Treatments for Myasthenia Gravis and Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis. Read more about them here.

Sleep Disorders

(7 currently active or recruiting studies) - Current clinical trails at Duke for patients with sleep disorders  include Brief Telehealth CBT-I Intervention in the Context of the COVID-19 Pandemic and Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension. Read more about them here.

Stroke

(16 currently active or recruiting studies) - Current clinical trails for patients with stroke at Duke include Transcranial Direct Current Stimulation for Post-stroke Motor Recovery and Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Read more about them here.

Traumatic Brain Injury (TBI)

(4 currently active or recruiting studies) - Current clinical trails for patients with traumatic brain injury at Duke include Hyperbaric Oxygen Brain Injury Treatment Trial and Neuromodulatory Treatments for Pain Management in TBI.  Read more about them here.